Publications

  1. Singh AK, Dadey DY, Rau MJ, Fitzpatrick J, Shah HK, Saikia M, Townsend R, Thotala D, Hallahan DE, Kapoor V. Blocking the functional domain of TIP1 by antibodies sensitizes cancer to radiation therapy. Biomed Pharmacother. 2023 Aug 23;166:115341. doi: 10.1016/j.biopha.2023.115341. Epub ahead of print. PMID: 37625322.
  2. Kapoor V, Singh AK, Lewis CD, Deore S, Hallahan DE. Exploiting Radiation Induction of Antigens in Cancer: Targeted Drug Delivery. Int. J. Mol. Sci. 2022, 23(6), 3041.
  3. Dadey DYA, Kapoor V, Khudanyan A, Thotala D, Hallahan DE. PERK Regulates Glioblastoma Sensitivity to ER Stress Although Promoting Radiation Resistance. Mol Cancer Res. 2018 Oct;16(10):1447-1453. doi: 10.1158/1541-7786.MCR-18-0224. Epub 2018 Jul 10. PMID: 29991528.
  4. Lin AJ, Campian JL, Hui C, Rudra S, Rao YJ, Thotala D, Hallahan D, Huang J.
    Impact of concurrent versus adjuvant chemotherapy on the severity and duration of lymphopenia in glioma patients treated with radiation therapy. J Neurooncol. 2018 Jan;136(2):403-411. doi: 10.1007/s11060-017-2668-5. Epub 2017 Nov 16. PubMed PMID: 29143923.
  5. Yan H, Kapoor V, Nguyen K, Akers WJ, Li H, Scott J, Laforest R, Rogers B, Thotala D, Hallahan D. Anti-tax interacting protein-1 (TIP-1) monoclonal antibody targets human cancers. Oncotarget. 2016 Jul 12;7(28):43352-43362. doi: 10.18632/oncotarget.9713. PubMed PMID: 27270318; PubMed Central PMCID:
    PMC5190028.
  6. Meyer B, Fabbrizi MR, Raj S, Zobel CL, Hallahan DE, Sharma GG. Histone H3 Lysine 9 Acetylation Obstructs ATM Activation and Promotes Ionizing Radiation Sensitivity in Normal Stem Cells. Stem Cell Reports. 2016 Dec 13;7(6):1013-1022. doi: 10.1016/j.stemcr.2016.11.004. PubMed PMID: 27974220; PubMed Central PMCID:
    PMC5161741.
  7. Dadey DYA, Kapoor V, Hoye K, Khudanyan A, Collins A, Thotala D, Hallahan DE. Antibody Targeting GRP78 Enhances the Efficacy of Radiation Therapy in Human Glioblastoma and Non-Small Cell Lung Cancer Cell Lines and Tumor Models. Clin Cancer Res. 2017 May 15;23(10):2556-2564. doi: 10.1158/1078-0432.CCR-16-1935. Epub 2016 Nov 4. PubMed PMID: 27815359.
  8. Kaliberov SA, Kaliberova LN, Yan H, Kapoor V, Hallahan DE. Retargeted adenoviruses for radiation-guided gene delivery. Cancer Gene Ther. 2016 Sep;23(9):303-14. doi: 10.1038/cgt.2016.32. Epub 2016 Aug 5. PubMed PMID: 27492853; PubMed Central PMCID: PMC5031535.
  9. Kapoor V, Dadey DY, Nguyen K, Wildman SA, Hoye K, Khudanyan A, Bandara N, Rogers BE, Thotala D, Hallahan DE. Tumor-Specific Binding of Radiolabeled PEGylated GIRLRG Peptide: A Novel Agent for Targeting Cancers. J Nucl Med. 2016 Dec;57(12):1991-1997. Epub 2016 Jul 21. PubMed PMID: 27445290; PubMed Central PMCID: PMC5126697.
  10. Jacobs KM, Misri S, Meyer B, Raj S, Zobel CL, Sleckman BP, Hallahan DE, Sharma GG. Unique epigenetic influence of H2AX phosphorylation and H3K56 acetylation on normal stem cell radioresponses. Mol Biol Cell. 2016 Apr 15;27(8):1332-45. doi: 10.1091/mbc.E16-01-0017. Epub 2016 Mar 3. PubMed PMID: 26941327; PubMed Central PMCID: PMC4831886.
  11. Dadey DY, Kapoor V, Khudanyan A, Urano F, Kim AH, Thotala D, Hallahan DE. The ATF6 pathway of the ER stress response contributes to enhanced viability in glioblastoma. Oncotarget. 2016 Jan 12;7(2):2080-92. doi: 10.18632/oncotarget.6712. PubMed PMID: 26716508; PubMed Central PMCID: PMC4811517.
  12. Thotala D, Karvas RM, Engelbach JA, Garbow JR, Hallahan AN, DeWees TA, Laszlo A, Hallahan DE. Valproic acid enhances the efficacy of radiation therapy by protecting normal hippocampal neurons and sensitizing malignant glioblastoma cells. Oncotarget. 2015 Oct 27;6(33):35004-22. doi: 10.18632/oncotarget.5253. PubMed PMID: 26413814; PubMed Central PMCID: PMC4741505.
  13. Zhao DY, Jacobs KM, Hallahan DE, Thotala D. Silencing Egr1 Attenuates Radiation-Induced Apoptosis in Normal Tissues while Killing Cancer Cells and Delaying Tumor Growth. Mol Cancer Ther. 2015 Oct;14(10):2343-52. doi: 10.1158/1535-7163.MCT-14-1051. Epub 2015 Jul 23. PubMed PMID: 26206332; PubMed Central PMCID: PMC4845655.
  14. Kapoor V, Khudanyan A, de la Puente P, Campian J, Hallahan DE, Azab AK, Thotala D. Stem Cell Transfusion Restores Immune Function in Radiation-Induced Lymphopenic C57BL/6 Mice. Cancer Res. 2015 Sep 1;75(17):3442-5. doi: 10.1158/0008-5472.CAN-15-1412. Epub 2015 Jun 30. PubMed PMID: 26130648.
  15. Jiang X, Perez-Torres CJ, Thotala D, Engelbach JA, Yuan L, Cates J, Gao F, Drzymala RE, Rich KM, Schmidt RE, Ackerman JJ, Hallahan DE, Garbow JR. A GSK-3β inhibitor protects against radiation necrosis in mouse brain. Int J Radiat Oncol Biol Phys. 2014 Jul 15;89(4):714-21. doi: 10.1016/j.ijrobp.2014.04.018. PubMed PMID: 24969790; PubMed Central PMCID: PMC4307920.
  16. Jiang X, Engelbach JA, Yuan L, Cates J, Gao F, Drzymala RE, Hallahan DE, Rich KM, Schmidt RE, Ackerman JJ, Garbow JR. Anti-VEGF antibodies mitigate the development of radiation necrosis in mouse brain. Clin Cancer Res. 2014 May 15;20(10):2695-702. doi: 10.1158/1078-0432.CCR-13-1941. Epub 2014 Mar 19. PubMed PMID: 24647570; PubMed Central PMCID: PMC4135174.
  17. Wang H, Han M, Whetsell W Jr, Wang J, Rich J, Hallahan D, Han Z. Tax-interacting protein 1 coordinates the spatiotemporal activation of Rho GTPases and regulates the infiltrative growth of human glioblastoma. Oncogene. 2014 Mar 20;33(12):1558-69. doi: 10.1038/onc.2013.97. Epub 2013 Apr 8. PubMed PMID: 23563176; PubMed Central PMCID: PMC3965267.
  18. Bhave SR, Dadey DY, Karvas RM, Ferraro DJ, Kotipatruni RP, Jaboin JJ, Hallahan AN, Dewees TA, Linkous AG, Hallahan DE, Thotala D. Autotaxin Inhibition with PF-8380 Enhances the Radiosensitivity of Human and Murine Glioblastoma Cell Lines. Front Oncol. 2013 Sep 17;3:236. doi: 10.3389/fonc.2013.00236. eCollection 2013. PubMed PMID: 24062988; PubMed Central PMCID: PMC3775313.
  19. Thotala D, Craft JM, Ferraro DJ, Kotipatruni RP, Bhave SR, Jaboin JJ, Hallahan DE. Cytosolic phospholipaseA2 inhibition with PLA-695 radiosensitizes tumors in lung cancer animal models. PLoS One. 2013 Jul 19;8(7):e69688. doi: 10.1371/journal.pone.0069688. Print 2013. PubMed PMID: 23894523; PubMed Central PMCID: PMC3716600.
  20. Laszlo A, Thotala D, Hallahan DE. Membrane phospholipids, EML4-ALK, and Hsp90 as novel targets in lung cancer treatment. Cancer J. 2013 May-Jun;19(3):238-46. doi: 10.1097/PPO.0b013e31829a68eb. Review. PubMed PMID: 23708071; PubMed Central
    PMCID: PMC3718064.
  21. Ferraro DJ, Bhave SR, Kotipatruni RP, Hunn JC, Wildman SA, Hong C, Dadey DY, Muhoro LK, Jaboin JJ, Thotala D, Hallahan DE. High-throughput identification of putative receptors for cancer-binding peptides using biopanning and microarray analysis. Integr Biol (Camb). 2013 Feb;5(2):342-50. doi: 10.1039/c2ib20187a. PubMed PMID: 23147990; PubMed Central PMCID: PMC3823383.
  22. Jacobs KM, Bhave SR, Ferraro DJ, Jaboin JJ, Hallahan DE, Thotala D. GSK-3β: A Bifunctional Role in Cell Death Pathways. Int J Cell Biol. 2012;2012:930710. doi: 10.1155/2012/930710. Epub 2012 May 21. PubMed PMID: 22675363; PubMed Central PMCID: PMC3364548.
  23. Craft JM, Hallahan D. Towards novel radiosensitizing agents: the role of cytosolic PLA2α in combined modality cancer therapy. Future Med Chem. 2011 May;3(7):835-43. doi: 10.4155/fmc.11.38. Review. PubMed PMID: 21644828; PubMed Central PMCID: PMC3443401.
  24. Schleicher SM, Thotala DK, Linkous AG, Hu R, Leahy KM, Yazlovitskaya EM, Hallahan DE. Autotaxin and LPA receptors represent potential molecular targets for the radiosensitization of murine glioma through effects on tumor vasculature. PLoS One. 2011;6(7):e22182. doi: 10.1371/journal.pone.0022182. Epub 2011 Jul 20. PubMed PMID: 21799791; PubMed Central PMCID: PMC3140496.
  25. Thotala DK, Hallahan DE, Yazlovitskaya EM. Glycogen synthase kinase 3β inhibitors protect hippocampal neurons from radiation-induced apoptosis by regulating MDM2-p53 pathway. Cell Death Differ. 2012 Mar;19(3):387-96. doi: 10.1038/cdd.2011.94. Epub 2011 Jul 8. PubMed PMID: 21738215; PubMed Central PMCID: PMC3193912.
  26. Schulte RR, Linkous AG, Hallahan DE, Yazlovitskaya EM. Cytosolic phospholipase A2 as a molecular target for the radiosensitization of ovarian cancer. Cancer Lett. 2011 May 28;304(2):137-43. doi: 10.1016/j.canlet.2011.02.015. PubMed PMID: 21397389; PubMed Central PMCID: PMC3075208.
  27. Hariri G, Wellons MS, Morris WH 3rd, Lukehart CM, Hallahan DE. Multifunctional FePt nanoparticles for radiation-guided targeting and imaging of cancer. Ann Biomed Eng. 2011 Mar;39(3):946-52. doi: 10.1007/s10439-010-0219-8. Epub 2010 Dec 4. PubMed PMID: 21132370; PubMed Central PMCID: PMC4401085.
  28. Dickey A, Schleicher S, Leahy K, Hu R, Hallahan D, Thotala DK. GSK-3β inhibition promotes cell death, apoptosis, and in vivo tumor growth delay in neuroblastoma Neuro-2A cell line. J Neurooncol. 2011 Aug;104(1):145-53. doi: 10.1007/s11060-010-0491-3. Epub 2010 Dec 16. PubMed PMID: 21161565; PubMed Central PMCID: PMC3151369.
  29. Wang H, Yan H, Fu A, Han M, Hallahan D, Han Z. TIP-1 translocation onto the cell plasma membrane is a molecular biomarker of tumor response to ionizing radiation. PLoS One. 2010 Aug 11;5(8):e12051. doi: 10.1371/journal.pone.0012051. PubMed PMID: 20711449; PubMed Central PMCID: PMC2920312.
  30. Lowery A, Onishko H, Hallahan DE, Han Z. Tumor-targeted delivery of liposome-encapsulated doxorubicin by use of a peptide that selectively binds to irradiated tumors. J Control Release. 2011 Feb 28;150(1):117-24. doi: 10.1016/j.jconrel.2010.11.006. Epub 2010 Nov 12. PubMed PMID: 21075152; PubMed Central PMCID: PMC3044774.
  31. Hariri G, Yan H, Wang H, Han Z, Hallahan DE. Radiation-guided drug delivery to mouse models of lung cancer. Clin Cancer Res. 2010 Oct 15;16(20):4968-77. doi: 10.1158/1078-0432.CCR-10-0969. Epub 2010 Aug 27. PubMed PMID: 20802016; PubMed Central PMCID: PMC2955851.
  32. Linkous AG, Yazlovitskaya EM, Hallahan DE. Cytosolic phospholipase A2 and lysophospholipids in tumor angiogenesis. J Natl Cancer Inst. 2010 Sep 22;102(18):1398-412. doi: 10.1093/jnci/djq290. Epub 2010 Aug 20. PubMed PMID: 20729478; PubMed Central PMCID: PMC2943523.
  33. Passarella RJ, Spratt DE, van der Ende AE, Phillips JG, Wu H, Sathiyakumar V, Zhou L, Hallahan DE, Harth E, Diaz R. Targeted nanoparticles that deliver a sustained, specific release of Paclitaxel to irradiated tumors. Cancer Res. 2010 Jun 1;70(11):4550-9. doi: 10.1158/0008-5472.CAN-10-0339. Epub 2010 May 18. PubMed PMID: 20484031; PubMed Central PMCID: PMC2880200.
  34. Perez CA, Fu A, Onishko H, Hallahan DE, Geng L. Radiation induces an antitumour immune response to mouse melanoma. Int J Radiat Biol. 2009 Dec;85(12):1126-36. doi: 10.3109/09553000903242099. PubMed PMID: 19995238.
  35. Passarella RJ, Zhou L, Phillips JG, Wu H, Hallahan DE, Diaz R. Recombinant peptides as biomarkers for tumor response to molecular targeted therapy. Clin Cancer Res. 2009 Oct 15;15(20):6421-9. doi: 10.1158/1078-0432.CCR-09-0945. Epub 2009 Oct 13. PubMed PMID: 19825959; PubMed Central PMCID: PMC2763341.
  36. Jaboin JJ, Han Z, Hallahan DE. Using in vivo biopanning for the development of radiation-guided drug delivery systems. Methods Mol Biol. 2009;542:285-300. doi: 10.1007/978-1-59745-561-9_15. PubMed PMID: 19565908.